Delayed Degradation and Impaired Dendritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice

Arc is a unique immediate early gene (IEG) whose expression is induced as synapses are modified during learning. Newly-synthesized Arc mRNA is rapidly transported throughout dendrites and localizes near recently activated synapses. Arc mRNA levels are regulated by rapid degradation, which is acceler...

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Udgivet i:Front Mol Neurosci
Main Authors: Steward, Oswald, Matsudaira Yee, Kelly, Farris, Shannon, Pirbhoy, Patricia S., Worley, Paul, Okamura, Kohji, Okuno, Hiroyuki, Bito, Haruhiko
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797788/
https://ncbi.nlm.nih.gov/pubmed/29445324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00435
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