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A novel GTPase, CRAG, mediates promyelocytic leukemia protein–associated nuclear body formation and degradation of expanded polyglutamine protein

Polyglutamine diseases are inherited neurodegenerative diseases caused by the expanded polyglutamine proteins (polyQs). We have identified a novel guanosine triphosphatase (GTPase) named CRAG that contains a nuclear localization signal (NLS) sequence and forms nuclear inclusions in response to stres...

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Main Authors: Qin, Qingyu, Inatome, Ryoko, Hotta, Azusa, Kojima, Masaki, Yamamura, Hirohei, Hirai, Hirokazu, Yoshizawa, Toshihiro, Tanaka, Hirofumi, Fukami, Kiyoko, Yanagi, Shigeru
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063670/
https://ncbi.nlm.nih.gov/pubmed/16461359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200505079
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