A novel GTPase, CRAG, mediates promyelocytic leukemia protein–associated nuclear body formation and degradation of expanded polyglutamine protein

Polyglutamine diseases are inherited neurodegenerative diseases caused by the expanded polyglutamine proteins (polyQs). We have identified a novel guanosine triphosphatase (GTPase) named CRAG that contains a nuclear localization signal (NLS) sequence and forms nuclear inclusions in response to stres...

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Detalhes bibliográficos
Main Authors: Qin, Qingyu, Inatome, Ryoko, Hotta, Azusa, Kojima, Masaki, Yamamura, Hirohei, Hirai, Hirokazu, Yoshizawa, Toshihiro, Tanaka, Hirofumi, Fukami, Kiyoko, Yanagi, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063670/
https://ncbi.nlm.nih.gov/pubmed/16461359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200505079
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