Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model

Using single-stranded adeno-associated virus serotype 9 (ssAAV9) vectors containing the neuron-specific synapsin-I promoter, we examined whether different administration routes (direct cerebellar cortical (DC), intrathecal (IT) and intravenous (IV) injections) could elicit specific transduction prof...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Huda, Fathul, Konno, Ayumu, Matsuzaki, Yasunori, Goenawan, Hanna, Miyake, Koichi, Shimada, Takashi, Hirai, Hirokazu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362361/
https://ncbi.nlm.nih.gov/pubmed/26015973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.32
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