CD4(+) T-cell subsets in inflammatory diseases: beyond the T(h)1/T(h)2 paradigm

von Hirahara, Kiyoshi, Nakayama, Toshinori
Veröffentlicht in Int Immunol (2016)

Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic airway inflammation

von Hirahara, Kiyoshi, Shinoda, Kenta, Endo, Yusuke, Ichikawa, Tomomi, Nakayama, Toshinori
Veröffentlicht in Inflamm Regen (2018)

The Role of CD4(+) Resident Memory T Cells in Local Immunity in the Mucosal Tissue – Protection Versus Pathology –

von Hirahara, Kiyoshi, Kokubo, Kota, Aoki, Ami, Kiuchi, Masahiro, Nakayama, Toshinori
Veröffentlicht in Front Immunol (2021)

Recent advances in understanding psoriasis

von Eberle, Franziska C., Brück, Jürgen, Holstein, Julia, Hirahara, Kiyoshi, Ghoreschi, Kamran
Veröffentlicht in F1000Res (2016)

Transcriptional and Epigenetic Control of T Cell Lineage Specification: Molecular Mechanisms Underlying Commitment and Plasticity

von Kanno, Yuka, Vahedi, Golnaz, Hirahara, Kiyoshi, Singleton, Kentner, O’Shea, John J.
Veröffentlicht 2012

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

von Ghoreschi, Kamran, Laurence, Arian, Yang, Xiang-Ping, Hirahara, Kiyoshi, O’Shea, John J.
Veröffentlicht 2011

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

von Hirahara, Kiyoshi, Ghoreschi, Kamran, Laurence, Arian, Yang, Xiang-ping, Kanno, Yuka, O’Shea, John J.
Veröffentlicht 2010

Immune Cell-Epithelial/Mesenchymal Interaction Contributing to Allergic Airway Inflammation Associated Pathology

von Hirahara, Kiyoshi, Shinoda, Kenta, Morimoto, Yuki, Kiuchi, Masahiro, Aoki, Ami, Kumagai, Jin, Kokubo, Kota, Nakayama, Toshinori
Veröffentlicht in Front Immunol (2019)

Helper T Cell Identity and Evolution of Differential Transcriptomes and Epigenomes

von Vahedi, Golnaz, Poholek, Amanda, Hand, Timothy W., Laurence, Arian, Kann, Yuka, O’Shea, John J., Hirahara, Kiyoshi
Veröffentlicht 2013

Mechanisms Underlying Helper T cell Plasticity: Implications for Immune-mediated Disease

von Hirahara, Kiyoshi, Poholek, Amanda, Vahedi, Golnaz, Laurence, Arian, Kanno, Yuka, Milner, Joshua D., O’Shea, John J.
Veröffentlicht 2013

Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes

von Onodera, Atsushi, Tumes, Damon J., Watanabe, Yukiko, Hirahara, Kiyoshi, Kaneda, Atsushi, Sugiyama, Fumihiro, Suzuki, Yutaka, Nakayama, Toshinori
Veröffentlicht in Mol Cell Biol (2015)

Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function

von Nigo, Yukiko I., Yamashita, Masakatsu, Hirahara, Kiyoshi, Shinnakasu, Ryo, Inami, Masamichi, Kimura, Motoko, Hasegawa, Akihiro, Kohno, Yoichi, Nakayama, Toshinori
Veröffentlicht 2006

Helper T-cell differentiation and plasticity: insights from epigenetics

von Hirahara, Kiyoshi, Vahedi, Golnaz, Ghoreschi, Kamran, Yang, Xiang-Ping, Nakayamada, Shingo, Kanno, Yuka, O'Shea, John J, Laurence, Arian
Veröffentlicht 2011

Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene

von Yamashita, Masakatsu, Kuwahara, Makoto, Suzuki, Akane, Hirahara, Kiyoshi, Shinnaksu, Ryo, Hosokawa, Hiroyuki, Hasegawa, Akihiro, Motohashi, Shinichiro, Iwama, Atsushi, Nakayama, Toshinori
Veröffentlicht 2008

Memory-type ST2(+)CD4(+) T cells participate in the steroid-resistant pathology of eosinophilic pneumonia

von Mato, Naoko, Hirahara, Kiyoshi, Ichikawa, Tomomi, Kumagai, Jin, Nakayama, Masayuki, Yamasawa, Hideaki, Bando, Masashi, Hagiwara, Koichi, Sugiyama, Yukihiko, Nakayama, Toshinori
Veröffentlicht in Sci Rep (2017)

CXCR6(+)ST2(+) memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth

von Obata-Ninomiya, Kazushige, Ishiwata, Kenji, Nakano, Hisanobu, Endo, Yusuke, Ichikawa, Tomomi, Onodera, Atsushi, Hirahara, Kiyoshi, Okamoto, Yoshitaka, Kanuka, Hirotaka, Nakayama, Toshinori
Veröffentlicht in Proc Natl Acad Sci U S A (2018)

The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4(+) T cell differentiation

von Kiuchi, Masahiro, Onodera, Atsushi, Kokubo, Kota, Ichikawa, Tomomi, Morimoto, Yuki, Kawakami, Eiryo, Takayama, Naoya, Eto, Koji, Koseki, Haruhiko, Hirahara, Kiyoshi, Nakayama, Toshinori
Veröffentlicht in J Exp Med (2021)

TGF-β and retinoic acid induce miR-10a, which targets Bcl-6 and constrains helper T cell plasticity

von Takahashi, Hayato, Kanno, Tomohiko, Nakayamada, Shingo, Hirahara, Kiyoshi, Sciumè, Giuseppe, Muljo, Stefan A., Kuchen, Stefan, Casellas, Rafael, Wei, Lai, Kanno, Yuka, O'Shea, John J.
Veröffentlicht 2012

Helper T cell plasticity: Impact of Extrinsic and Intrinsic Signals On Transcriptomes and Epigenomes

von Bonelli, Michael, Shih, Han-Yu, Hirahara, Kiyoshi, Singelton, Kentner, Laurence, Arian, Poholek, Amanda, Hand, Tim, Mikami, Yohei, Vahedi, Golnaz, Kanno, Yuka, O'Shea, John J.
Veröffentlicht 2014

Transcriptional and epigenetic networks that drive helper T cell identities

von Shih, Han-Yu, Sciumè, Giuseppe, Poholek, Amanda C, Vahedi, Golnaz, Hirahara, Kiyoshi, Villarino, Alejandro V, Bonelli, Michael, Bosselut, Remy, Kanno, Yuka, Muljo, Stefan A, O’Shea, John J.
Veröffentlicht in Immunol Rev (2014)