Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene

The maintenance of memory T cells is central to the establishment of immunological memory, although molecular details of the process are poorly understood. In the absence of the polycomb group (PcG) gene Bmi1, the number of memory CD4(+) T helper (Th)1/Th2 cells was reduced significantly. Enhanced c...

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Detalhes bibliográficos
Main Authors: Yamashita, Masakatsu, Kuwahara, Makoto, Suzuki, Akane, Hirahara, Kiyoshi, Shinnaksu, Ryo, Hosokawa, Hiroyuki, Hasegawa, Akihiro, Motohashi, Shinichiro, Iwama, Atsushi, Nakayama, Toshinori
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373843/
https://ncbi.nlm.nih.gov/pubmed/18411339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072000
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