The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation

Sox4 is a transcription factor that regulates various developmental processes. Here we show that Sox4 was induced by TGF-β and negatively regulated the transcription factor GATA-3, the master regulator of function of T helper type 2 (T(H)2) cells, by two distinct mechanisms. First, Sox4 bound direct...

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Bibliografiske detaljer
Main Authors: Kuwahara, Makoto, Yamashita, Masakatsu, Shinoda, Kenta, Tofukuji, Soichi, Onodera, Atsushi, Shinnakasu, Ryo, Motohashi, Shinichiro, Hosokawa, Hiroyuki, Tumes, Damon, Iwamura, Chiaki, Lefebvre, Veronique, Nakayama, Toshinori
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477402/
https://ncbi.nlm.nih.gov/pubmed/22751141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2362
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