Gfi1-mediated Stabilization of GATA3 Protein Is Required for Th2 Cell Differentiation

The differentiation of naive CD4 T cells into Th2 cells requires the T cell receptor-mediated activation of the ERK MAPK cascade. Little is known, however, in regard to how the ERK MAPK cascade regulates Th2 cell differentiation. We herein identified Gfi1 (growth factor independent-1) as a downstrea...

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Bibliografiske detaljer
Main Authors: Shinnakasu, Ryo, Yamashita, Masakatsu, Kuwahara, Makoto, Hosokawa, Hiroyuki, Hasegawa, Akihiro, Motohashi, Shinichiro, Nakayama, Toshinori
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661392/
https://ncbi.nlm.nih.gov/pubmed/18701459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804174200
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