Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

par Mazharian, Alexandra, Mori, Jun, Wang, Ying-Jie, Heising, Silke, Neel, Benjamin G., Watson, Steve P., Senis, Yotis A.
Publié 2013

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions

par Nagy, Zoltan, Vögtle, Timo, Geer, Mitchell J., Mori, Jun, Heising, Silke, Di Nunzio, Giada, Gareus, Ralph, Tarakhovsky, Alexander, Weiss, Arthur, Neel, Benjamin G., Desanti, Guillaume E., Mazharian, Alexandra, Senis, Yotis A.
Publié dans Blood (2019)

Induction of the nicotinamide riboside kinase NAD(+) salvage pathway in a model of sarcoplasmic reticulum dysfunction

par Doig, Craig L., Zielinska, Agnieszka E., Fletcher, Rachel S., Oakey, Lucy A., Elhassan, Yasir S., Garten, Antje, Cartwright, David, Heising, Silke, Alsheri, Ahmed, Watson, David G., Prehn, Cornelia, Adamski, Jerzy, Tennant, Daniel A., Lavery, Gareth G.
Publié dans Skelet Muscle (2020)

Mice Lacking the ITIM-Containing Receptor G6b-B Exhibit Macrothrombocytopenia and Aberrant Platelet Function

par Mazharian, Alexandra, Wang, Ying-Jie, Mori, Jun, Bem, Danai, Finney, Brenda, Heising, Silke, Gissen, Paul, White, James G., Berndt, Michael C., Gardiner, Elizabeth E., Nieswandt, Bernhard, Douglas, Michael R., Campbell, Robert D., Watson, Steve P., Senis, Yotis A.
Publié dans Sci Signal (2012)

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

par Geer, Mitchell J., van Geffen, Johanna P., Gopalasingam, Piraveen, Vögtle, Timo, Smith, Christopher W., Heising, Silke, Kuijpers, Marijke J. E., Tullemans, Bibian M. E., Jarvis, Gavin E., Eble, Johannes A., Jeeves, Mark, Overduin, Michael, Heemskerk, Johan W. M., Mazharian, Alexandra, Senis, Yotis A.
Publié dans Blood (2018)

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148

par Mori, Jun, Nagy, Zoltan, Di Nunzio, Giada, Smith, Christopher W., Geer, Mitchell J., Al Ghaithi, Rashid, van Geffen, Johanna P., Heising, Silke, Boothman, Luke, Tullemans, Bibian M. E., Correia, Joao N., Tee, Louise, Kuijpers, Marijke J. E., Harrison, Paul, Heemskerk, Johan W. M., Jarvis, Gavin E., Tarakhovsky, Alexander, Weiss, Arthur, Mazharian, Alexandra, Senis, Yotis A.
Publié dans Blood (2018)

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

par Viloria, Katrina, Nasteska, Daniela, Briant, Linford J.B., Heising, Silke, Larner, Dean P., Fine, Nicholas H.F., Ashford, Fiona B., da Silva Xavier, Gabriela, Ramos, Maria Jiménez, Hasib, Annie, Cuozzo, Federica, Manning Fox, Jocelyn E., MacDonald, Patrick E., Akerman, Ildem, Lavery, Gareth G., Flaxman, Christine, Morgan, Noel G., Richardson, Sarah J., Hewison, Martin, Hodson, David J.
Publié dans Cell Rep (2020)

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice

par Hofmann, Inga, Geer, Mitchell J., Vögtle, Timo, Crispin, Andrew, Campagna, Dean R., Barr, Alastair, Calicchio, Monica L., Heising, Silke, van Geffen, Johanna P., Kuijpers, Marijke J. E., Heemskerk, Johan W. M., Eble, Johannes A., Schmitz-Abe, Klaus, Obeng, Esther A., Douglas, Michael, Freson, Kathleen, Pondarré, Corinne, Favier, Rémi, Jarvis, Gavin E., Markianos, Kyriacos, Turro, Ernest, Ouwehand, Willem H., Mazharian, Alexandra, Fleming, Mark D., Senis, Yotis A.
Publié dans Blood (2018)