Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

The immunoreceptor tyrosine-based inhibitory motif (ITIM)–containing receptor G6b-B has emerged as a key regulator of platelet homeostasis. However, it remains unclear how it mediates its effects. Tyrosine phosphorylation of ITIM and immunoreceptor tyrosine-based switch motif (ITSM) within the cytop...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Geer, Mitchell J., van Geffen, Johanna P., Gopalasingam, Piraveen, Vögtle, Timo, Smith, Christopher W., Heising, Silke, Kuijpers, Marijke J. E., Tullemans, Bibian M. E., Jarvis, Gavin E., Eble, Johannes A., Jeeves, Mark, Overduin, Michael, Heemskerk, Johan W. M., Mazharian, Alexandra, Senis, Yotis A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212653/
https://ncbi.nlm.nih.gov/pubmed/29891536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-10-802975
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