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Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

The SH2 domain-containing protein-tyrosine phosphatases Shp1 and Shp2 have been implicated in regulating signaling from a variety of platelet and megakaryocyte receptors. In this study, we investigate the functions of Shp1 and Shp2 in megakaryocytes and platelets. Megakaryocyte/platelet (MP)-specifi...

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Detalhes bibliográficos
Main Authors: Mazharian, Alexandra, Mori, Jun, Wang, Ying-Jie, Heising, Silke, Neel, Benjamin G., Watson, Steve P., Senis, Yotis A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656453/
https://ncbi.nlm.nih.gov/pubmed/23509158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-449272
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