Induction of the nicotinamide riboside kinase NAD(+) salvage pathway in a model of sarcoplasmic reticulum dysfunction

BACKGROUND: Hexose-6-Phosphate Dehydrogenase (H6PD) is a generator of NADPH in the Endoplasmic/Sarcoplasmic Reticulum (ER/SR). Interaction of H6PD with 11β-hydroxysteroid dehydrogenase type 1 provides NADPH to support oxo-reduction of inactive to active glucocorticoids, but the wider understanding o...

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Опубликовано в: :Skelet Muscle
Главные авторы: Doig, Craig L., Zielinska, Agnieszka E., Fletcher, Rachel S., Oakey, Lucy A., Elhassan, Yasir S., Garten, Antje, Cartwright, David, Heising, Silke, Alsheri, Ahmed, Watson, David G., Prehn, Cornelia, Adamski, Jerzy, Tennant, Daniel A., Lavery, Gareth G.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2020
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031948/
https://ncbi.nlm.nih.gov/pubmed/32075690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-019-0216-z
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