Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148

Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase (Csk) and receptor-like protein tyrosine-phosphatase CD148 in mice results in a dramatic increase i...

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Veröffentlicht in:Blood
Hauptverfasser: Mori, Jun, Nagy, Zoltan, Di Nunzio, Giada, Smith, Christopher W., Geer, Mitchell J., Al Ghaithi, Rashid, van Geffen, Johanna P., Heising, Silke, Boothman, Luke, Tullemans, Bibian M. E., Correia, Joao N., Tee, Louise, Kuijpers, Marijke J. E., Harrison, Paul, Heemskerk, Johan W. M., Jarvis, Gavin E., Tarakhovsky, Alexander, Weiss, Arthur, Mazharian, Alexandra, Senis, Yotis A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2018
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888341/
https://ncbi.nlm.nih.gov/pubmed/29301754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-768077
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