Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148

Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase (Csk) and receptor-like protein tyrosine-phosphatase CD148 in mice results in a dramatic increase i...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Mori, Jun, Nagy, Zoltan, Di Nunzio, Giada, Smith, Christopher W., Geer, Mitchell J., Al Ghaithi, Rashid, van Geffen, Johanna P., Heising, Silke, Boothman, Luke, Tullemans, Bibian M. E., Correia, Joao N., Tee, Louise, Kuijpers, Marijke J. E., Harrison, Paul, Heemskerk, Johan W. M., Jarvis, Gavin E., Tarakhovsky, Alexander, Weiss, Arthur, Mazharian, Alexandra, Senis, Yotis A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888341/
https://ncbi.nlm.nih.gov/pubmed/29301754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-768077
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