Too much or too little: Harnessing senescence to control oncogene-driven cancer

著者: Hannan, Katherine M., Pearson, Richard B.
出版事項 2012

Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex.

著者: Hannan, Katherine M, Thomas, George, Pearson, Richard B
出版事項 2003

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

著者: Ferreira, Rita, Schneekloth, John S., Panov, Konstantin I., Hannan, Katherine M., Hannan, Ross D.
出版年 Cells (2020)

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity

著者: Lee, Rachel S., House, Colin M., Cristiano, Briony E., Hannan, Ross D., Pearson, Richard B., Hannan, Katherine M.
出版事項 2011

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

著者: Yan, Shunfei, Frank, Daniel, Son, Jinbae, Hannan, Katherine M., Hannan, Ross D., Chan, Keefe T., Pearson, Richard B., Sanij, Elaine
出版年 Int J Mol Sci (2017)

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

著者: Kerry, Louise E., Pegg, Elaine E., Cameron, Donald P., Budzak, James, Poortinga, Gretchen, Hannan, Katherine M., Hannan, Ross D., Rudenko, Gloria
出版年 PLoS Negl Trop Dis (2017)

mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription...

著者: Hannan, Katherine M., Brandenburger, Yves, Jenkins, Anna, Sharkey, Kerith, Cavanaugh, Alice, Rothblum, Lawrence, Moss, Tom, Poortinga, Gretchen, McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.
出版事項 2003

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

著者: Son, Jinbae, Hannan, Katherine M., Poortinga, Gretchen, Hein, Nadine, Cameron, Donald P., Ganley, Austen R. D., Sheppard, Karen E., Pearson, Richard B., Hannan, Ross D., Sanij, Elaine
出版年 Front Cell Dev Biol (2020)

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

著者: Kang, Jian, Kusnadi, Eric P., Ogden, Allison J., Hicks, Rodney J., Bammert, Lukas, Kutay, Ulrike, Hung, Sandy, Sanij, Elaine, Hannan, Ross D., Hannan, Katherine M., Pearson, Richard B.
出版年 Oncotarget (2016)

MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

著者: Poortinga, Gretchen, Hannan, Katherine M, Snelling, Hayley, Walkley, Carl R, Jenkins, Anna, Sharkey, Kerith, Wall, Meaghan, Brandenburger, Yves, Palatsides, Manuela, Pearson, Richard B, McArthur, Grant A, Hannan, Ross D
出版事項 2004

A functional genetic screen defines the AKT-induced senescence signaling network

著者: Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D., George, Amee J., Sanij, Elaine, Hannan, Katherine M., Simpson, Kaylene J., Pearson, Richard B.
出版年 Cell Death Differ (2019)

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-gra...

著者: Yan, Shunfei, Xuan, Jiachen, Brajanovski, Natalie, Tancock, Madeleine R. C., Madhamshettiwar, Piyush B., Simpson, Kaylene J., Ellis, Sarah, Kang, Jian, Cullinane, Carleen, Sheppard, Karen E., Hannan, Katherine M., Hannan, Ross D., Sanij, Elaine, Pearson, Richard B., Chan, Keefe T.
出版年 Br J Cancer (2020)

UBF levels determine the number of active ribosomal RNA genes in mammals

著者: Sanij, Elaine, Poortinga, Gretchen, Sharkey, Kerith, Hung, Sandy, Holloway, Timothy P., Quin, Jaclyn, Robb, Elysia, Wong, Lee H., Thomas, Walter G., Stefanovsky, Victor, Moss, Tom, Rothblum, Lawrence, Hannan, Katherine M., McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.
出版事項 2008

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

著者: Shortt, Jake, Martin, Benjamin P., Newbold, Andrea, Hannan, Katherine M., Devlin, Jennifer R., Baker, Adele J., Ralli, Rachael, Cullinane, Carleen, Schmitt, Clemens A., Reimann, Maurice, Hall, Michael N., Wall, Meaghan, Hannan, Ross D., Pearson, Richard B., McArthur, Grant A., Johnstone, Ricky W.
出版事項 2013

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

著者: Kusnadi, Eric P, Trigos, Anna S, Cullinane, Carleen, Goode, David L, Larsson, Ola, Devlin, Jennifer R, Chan, Keefe T, De Souza, David P, McConville, Malcolm J, McArthur, Grant A, Thomas, George, Sanij, Elaine, Poortinga, Gretchen, Hannan, Ross D, Hannan, Katherine M, Kang, Jian, Pearson, Richard B
出版年 EMBO J (2020)

The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence

著者: Wall, Meaghan, Poortinga, Gretchen, Stanley, Kym L, Lindemann, Ralph K, Bots, Michael, Chan, Christopher J, Bywater, Megan J, Kinross, Kathryn M, Astle, Megan V, Waldeck, Kelly, Hannan, Katherine M, Shortt, Jake, Smyth, Mark J, Lowe, Scott W, Hannan, Ross D, Pearson, Richard B, Johnstone, Ricky W, McArthur, Grant A
出版事項 2012

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

著者: Quin, Jaclyn, Chan, Keefe T., Devlin, Jennifer R., Cameron, Donald P., Diesch, Jeannine, Cullinane, Carleen, Ahern, Jessica, Khot, Amit, Hein, Nadine, George, Amee J., Hannan, Katherine M, Poortinga, Gretchen, Sheppard, Karen E., Khanna, Kum Kum, Johnstone, Ricky W., Drygin, Denis, McArthur, Grant A., Pearson, Richard B., Sanij, Elaine, Hannan, Ross D.
出版年 Oncotarget (2016)

Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis

著者: Boglev, Yeliz, Badrock, Andrew P., Trotter, Andrew J., Du, Qian, Richardson, Elsbeth J., Parslow, Adam C., Markmiller, Sebastian J., Hall, Nathan E., de Jong-Curtain, Tanya A., Ng, Annie Y., Verkade, Heather, Ober, Elke A., Field, Holly A., Shin, Donghun, Shin, Chong H., Hannan, Katherine M., Hannan, Ross D., Pearson, Richard B., Kim, Seok-Hyung, Ess, Kevin C., Lieschke, Graham J., Stainier, Didier Y. R., Heath, Joan K.
出版事項 2013

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

著者: Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.
出版年 Nat Commun (2020)

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

著者: Hein, Nadine, Cameron, Donald P., Hannan, Katherine M., Nguyen, Nhu-Y N., Fong, Chun Yew, Sornkom, Jirawas, Wall, Meaghan, Pavy, Megan, Cullinane, Carleen, Diesch, Jeannine, Devlin, Jennifer R., George, Amee J., Sanij, Elaine, Quin, Jaclyn, Poortinga, Gretchen, Verbrugge, Inge, Baker, Adele, Drygin, Denis, Harrison, Simon J., Rozario, James D., Powell, Jason A., Pitson, Stuart M., Zuber, Johannes, Johnstone, Ricky W., Dawson, Mark A., Guthridge, Mark A., Wei, Andrew, McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.
出版年 Blood (2017)