Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity

The AKT protooncogene mediates many cellular processes involved in normal development and disease states such as cancer. The three structurally similar isoforms: AKT1, AKT2, and AKT3 exhibit both functional redundancy and isoform-specific functions; however the basis for their differential signallin...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Rachel S., House, Colin M., Cristiano, Briony E., Hannan, Ross D., Pearson, Richard B., Hannan, Katherine M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: SAGE-Hindawi Access to Research 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160084/
https://ncbi.nlm.nih.gov/pubmed/21869924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/720985
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