Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation

Por Imai, Rika, Asai, Kanae, Hanai, Jun-ichi, Takenaka, Masaru
Publicado no Aging (Albany NY) (2015)

Cellular Actions and Signaling by Endostatin

Por Ramchandran, Ramani, Karumanchi, S. Ananth, Hanai, Jun-ichi, Alper, Seth L., Sukhatme, Vikas P.
Publicado em 2002

Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect

Por Cao, Peirang, Hanai, Jun-ichi, Tanksale, Preeti, Imamura, Shintaro, Sukhatme, Vikas P., Lecker, Stewart H.
Publicado em 2009

Inhibition of Lung Cancer Growth: ATP Citrate Lyase Knockdown and Statin Treatment Leads to Dual Blockade of Mitogen-Activated Protein Kinase (MAPK) and Phosphatidylinositol-3-Kina...

Por HANAI, JUN-ICHI, DORO, NATHANIEL, SASAKI, ATSUO T., KOBAYASHI, SUSUMU, CANTLEY, LEWIS C., SETH, PANKAJ, SUKHATME, VIKAS P.
Publicado em 2012

Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway

Por Ren, Jian-Guo, Seth, Pankaj, Ye, Huihui, Guo, Kun, Hanai, Jun-ichi, Husain, Zaheed, Sukhatme, Vikas P.
Publicado no Sci Rep (2017)

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model

Por Koshimizu, Eriko, Imamura, Shintaro, Qi, Jie, Toure, Jamal, Valdez, Delgado M., Carr, Christopher E., Hanai, Jun-ichi, Kishi, Shuji
Publicado em 2011

A RUNX2/PEBP2αA/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

Por Zhang, Yu-Wen, Yasui, Natsuo, Ito, Kosei, Huang, Gang, Fujii, Makiko, Hanai, Jun-ichi, Nogami, Hiroshi, Ochi, Takahiro, Miyazono, Kohei, Ito, Yoshiaki
Publicado em 2000

Endostatin is a potential inhibitor of Wnt signaling

Por Hanai, Jun-ichi, Gloy, Joachim, Karumanchi, S. Ananth, Kale, Sujata, Tang, Jian, Hu, Guang, Chan, Barden, Ramchandran, Ramani, Jha, Vivek, Sukhatme, Vikas P., Sokol, Sergei
Publicado em 2002

The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity

Por Hanai, Jun-ichi, Cao, Peirang, Tanksale, Preeti, Imamura, Shintaro, Koshimizu, Eriko, Zhao, Jinghui, Kishi, Shuji, Yamashita, Michiaki, Phillips, Paul S., Sukhatme, Vikas P., Lecker, Stewart H.
Publicado em 2007

Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA

Por Miura, Shigeto, Takeshita, Toshikazu, Asao, Hironobu, Kimura, Yutaka, Murata, Kazuko, Sasaki, Yoshiteru, Hanai, Jun-Ichi, Beppu, Hideyuki, Tsukazaki, Tomoo, Wrana, Jeffrey L., Miyazono, Kohei, Sugamura, Kazuo
Publicado em 2000

A small-molecule screening strategy to identify suppressors of statin myopathy

Por Wagner, Bridget K., Gilbert, Tamara J., Hanai, Jun-ichi, Imamura, Shintaro, Bodycombe, Nicole E., Bon, Robin S., Waldmann, Herbert, Clemons, Paul A., Sukhatme, Vikas P., Mootha, Vamsi K.
Publicado em 2011

Parathyroid hormone controls paracellular Ca(2+) transport in the thick ascending limb by regulating the tight-junction protein Claudin14

Por Sato, Tadatoshi, Courbebaisse, Marie, Ide, Noriko, Fan, Yi, Hanai, Jun-ichi, Kaludjerovic, Jovana, Densmore, Michael J., Yuan, Quan, Toka, Hakan R., Pollak, Martin R., Hou, Jianghui, Lanske, Beate
Publicado no Proc Natl Acad Sci U S A (2017)

A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis

Por Imamura, Shintaro, Uchiyama, Junzo, Koshimizu, Eriko, Hanai, Jun-ichi, Raftopoulou, Christina, Murphey, Ryan D., Bayliss, Peter E., Imai, Yoichi, Burns, Caroline Erter, Masutomi, Kenkichi, Gagos, Sarantis, Zon, Leonard I., Roberts, Thomas M., Kishi, Shuji
Publicado em 2008

Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate

Por Fan, Yi, Hanai, Jun-ichi, Le, Phuong T., Bi, Ruiye, Maridas, David, DeMambro, Victoria, Figueroa, Carolina A., Kir, Serkan, Zhou, Xuedong, Mannstadt, Michael, Baron, Roland, Bronson, Roderick T., Horowitz, Mark C., Wu, Joy Y., Bilezikian, John P., Dempster, David W., Rosen, Clifford J., Lanske, Beate
Publicado no Cell Metab (2017)

Targeting lactate dehydrogenase-A inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells

Por Xie, Han, Hanai, Jun-ichi, Ren, Jian-Guo, Kats, Lev, Burgess, Kerri, Bhargava, Parul, Signoretti, Sabina, Billiard, Julia, Duffy, Kevin J., Grant, Aaron, Wang, Xiaoen, Lorkiewicz, Pawel K., Schatzman, Sabrina, Bousamra, Michael, Lane, Andrew N., Higashi, Richard M., Fan, Teresa W.M., Pandolfi, Pier Paolo, Sukhatme, Vikas P., Seth, Pankaj
Publicado em 2014