Parathyroid hormone controls paracellular Ca(2+) transport in the thick ascending limb by regulating the tight-junction protein Claudin14

Renal Ca(2+) reabsorption is essential for maintaining systemic Ca(2+) homeostasis and is tightly regulated through the parathyroid hormone (PTH)/PTHrP receptor (PTH1R) signaling pathway. We investigated the role of PTH1R in the kidney by generating a mouse model with targeted deletion of PTH1R in t...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sato, Tadatoshi, Courbebaisse, Marie, Ide, Noriko, Fan, Yi, Hanai, Jun-ichi, Kaludjerovic, Jovana, Densmore, Michael J., Yuan, Quan, Toka, Hakan R., Pollak, Martin R., Hou, Jianghui, Lanske, Beate
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402431/
https://ncbi.nlm.nih.gov/pubmed/28373577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616733114
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