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A small-molecule screening strategy to identify suppressors of statin myopathy
The reduction of plasma low-density lipoprotein levels by HMG-CoA reductase inhibitors, or statins, has had a revolutionary impact in medicine, but muscle-related side effects remain a dose-limiting toxicity in many patients. We describe a chemical epistasis approach that can be useful in refining t...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176973/ https://ncbi.nlm.nih.gov/pubmed/21732624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200206w |
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