A small-molecule screening strategy to identify suppressors of statin myopathy

The reduction of plasma low-density lipoprotein levels by HMG-CoA reductase inhibitors, or statins, has had a revolutionary impact in medicine, but muscle-related side effects remain a dose-limiting toxicity in many patients. We describe a chemical epistasis approach that can be useful in refining t...

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Autori principali: Wagner, Bridget K., Gilbert, Tamara J., Hanai, Jun-ichi, Imamura, Shintaro, Bodycombe, Nicole E., Bon, Robin S., Waldmann, Herbert, Clemons, Paul A., Sukhatme, Vikas P., Mootha, Vamsi K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176973/
https://ncbi.nlm.nih.gov/pubmed/21732624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200206w
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