The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity

Statins inhibit HMG-CoA reductase, a key enzyme in cholesterol synthesis, and are widely used to treat hypercholesterolemia. These drugs can lead to a number of side effects in muscle, including muscle fiber breakdown; however, the mechanisms of muscle injury by statins are poorly understood. We rep...

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Detalhes bibliográficos
Main Authors: Hanai, Jun-ichi, Cao, Peirang, Tanksale, Preeti, Imamura, Shintaro, Koshimizu, Eriko, Zhao, Jinghui, Kishi, Shuji, Yamashita, Michiaki, Phillips, Paul S., Sukhatme, Vikas P., Lecker, Stewart H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2066198/
https://ncbi.nlm.nih.gov/pubmed/17992259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32741
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