Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism of action is unclear. We genetically deleted the PTH/PTHrP Receptor (PTH1R) in mesenchymal stem cells using Prx1Cre and found low bone formation, increased bone resorption and high bone marrow adipose tissue (...

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Publicat a:Cell Metab
Autors principals: Fan, Yi, Hanai, Jun-ichi, Le, Phuong T., Bi, Ruiye, Maridas, David, DeMambro, Victoria, Figueroa, Carolina A., Kir, Serkan, Zhou, Xuedong, Mannstadt, Michael, Baron, Roland, Bronson, Roderick T., Horowitz, Mark C., Wu, Joy Y., Bilezikian, John P., Dempster, David W., Rosen, Clifford J., Lanske, Beate
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342925/
https://ncbi.nlm.nih.gov/pubmed/28162969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.01.001
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