Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism of action is unclear. We genetically deleted the PTH/PTHrP Receptor (PTH1R) in mesenchymal stem cells using Prx1Cre and found low bone formation, increased bone resorption and high bone marrow adipose tissue (...

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Udgivet i:Cell Metab
Main Authors: Fan, Yi, Hanai, Jun-ichi, Le, Phuong T., Bi, Ruiye, Maridas, David, DeMambro, Victoria, Figueroa, Carolina A., Kir, Serkan, Zhou, Xuedong, Mannstadt, Michael, Baron, Roland, Bronson, Roderick T., Horowitz, Mark C., Wu, Joy Y., Bilezikian, John P., Dempster, David W., Rosen, Clifford J., Lanske, Beate
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342925/
https://ncbi.nlm.nih.gov/pubmed/28162969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.01.001
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