Direct Subunit-Dependent Multimodal 5-Hydroxytryptamine(3) Receptor Antagonism by Methadone

por Deeb, Tarek Z., Sharp, Douglas, Hales, Tim G.
Publicado 2009

Loop G in the GABA(A) receptor α1 subunit influences gating efficacy

por Baptista‐Hon, Daniel T., Gulbinaite, Simona, Hales, Tim G.
Publicado en J Physiol (2017)

β-Arrestin2 and c-Src Regulate the Constitutive Activity and Recycling of μ Opioid Receptors in Dorsal Root Ganglion Neurons

por Walwyn, Wendy, Evans, Christopher J., Hales, Tim G.
Publicado en J Neurosci (2007)

Modulation by general anaesthetics of rat GABA(A) receptors comprised of α1β3 and β3 subunits expressed in human embryonic kidney 293 cells

por Davies, Paul A, Kirkness, Ewen F, Hales, Tim G
Publicado 1997

Evidence for the formation of functionally distinct αβγε GABA(A) receptors

por Davies, Paul A, Kirkness, Ewen F, Hales, Tim G
Publicado 2001

A role for loop G in the β1 strand in GABA(A) receptor activation

por Baptista‐Hon, Daniel T., Krah, Alexander, Zachariae, Ulrich, Hales, Tim G.
Publicado en J Physiol (2016)

A structural rationale for N-methylbicuculline acting as a promiscuous competitive antagonist of inhibitory pentameric ligand gated ion channels

por Jones, Mathew J., Dawson, Alice, Hales, Tim G., Hunter, William N.
Publicado en Chembiochem (2020)

δ Receptors Are Required for Full Inhibitory Coupling of μ Receptors to Voltage-Dependent Ca(2+) Channels in Dorsal Root Ganglion Neurons

por Walwyn, Wendy, John, Scott, Maga, Matthew, Evans, Christopher J., Hales, Tim G.
Publicado 2009

Agonist- and antagonist-induced up-regulation of surface 5-HT(3)A receptors

por Morton, Russell A, Baptista-Hon, Daniel T, Hales, Tim G, Lovinger, David M
Publicado en Br J Pharmacol (2015)

Amino acid substitutions in the human homomeric β(3) GABA(A) receptor that enable activation by GABA

por Gottschald Chiodi, Carla, Baptista-Hon, Daniel T., Hunter, William N., Hales, Tim G.
Publicado en J Biol Chem (2019)

High Affinity Binding of Epibatidine to Serotonin Type 3 Receptors

por Drisdel, Renaldo C., Sharp, Douglas, Henderson, Tricia, Hales, Tim G., Green, William N.
Publicado 2008

The 5-HT(3) receptor - the relationship between structure and function

por Barnes, Nicholas M., Hales, Tim G., Lummis, Sarah C.R., Peters, John A.
Publicado en Neuropharmacology (2008)

Kinetics and Spontaneous Open Probability Conferred by the ϵ Subunit of the GABA(A) Receptor

por Wagner, David A., Goldschen-Ohm, Marcel P., Hales, Tim G., Jones, Mathew V.
Publicado en J Neurosci (2005)

Fluorophore assisted light inactivation (FALI) of recombinant 5-HT(3)A receptor constitutive internalization and function

por Morton, Russell A., Luo, Guoxiang, Davis, Margaret I., Hales, Tim G., Lovinger, David M.
Publicado 2011

The 5-HT3B subunit affects high-potency inhibition of 5-HT(3) receptors by morphine

por Baptista-Hon, Daniel T, Deeb, Tarek Z, Othman, Nidaa A, Sharp, Douglas, Hales, Tim G
Publicado 2012

Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src

por Bull, Fiona A., Baptista-Hon, Daniel T., Lambert, Jeremy J., Walwyn, Wendy, Hales, Tim G.
Publicado en Sci Rep (2017)

The Minimum M3-M4 Loop Length of Neurotransmitter-activated Pentameric Receptors Is Critical for the Structural Integrity of Cytoplasmic Portals

por Baptista-Hon, Daniel T., Deeb, Tarek Z., Lambert, Jeremy J., Peters, John A., Hales, Tim G.
Publicado 2013

Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation

por Bull, Fiona A., Baptista-Hon, Daniel T., Sneddon, Claire, Wright, Lisa, Walwyn, Wendy, Hales, Tim G.
Publicado en Anesthesiology (2017)

The search for the “next” euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning

por Sharma, Kirti Kumari, Hales, Tim G., Rao, Vaidya Jayathirtha, NicDaeid, Niamh, McKenzie, Craig
Publicado en Forensic Toxicol (2018)

A conserved cysteine residue in the third transmembrane domain is essential for homomeric 5-HT(3) receptor function

por Wu, Dai-Fei, Othman, Nidaa A, Sharp, Douglas, Mahendra, Arjun, Deeb, Tarek Z, Hales, Tim G
Publicado 2010