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Amino acid substitutions in the human homomeric β(3) GABA(A) receptor that enable activation by GABA
GABA(A) receptors (GABA(A)Rs) are pentameric ligand-gated ion channels that mediate synaptic inhibition throughout the central nervous system. The α(1)β(2)γ(2) receptor is the major subtype in the brain; GABA binds at the β(2)(+)α(1)(−) interface. The structure of the homomeric β(3) GABA(A)R, which...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6378970/ https://ncbi.nlm.nih.gov/pubmed/30545943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006229 |
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