A Sweet Delivery for a Really Bitter Pill: Globo H and RNase 1

Por Hosono, Masahiro
Publicado no ACS Cent Sci (2015)

Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma

Por Satoh, Toshiyuki, Tatsuta, Takeo, Sugawara, Shigeki, Hara, Akiyoshi, Hosono, Masahiro
Publicado no Oncotarget (2017)

Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo

Por Tatsuta, Takeo, Satoh, Toshiyuki, Sugawara, Shigeki, Hara, Akiyoshi, Hosono, Masahiro
Publicado no PLoS One (2018)

Downregulation of Hsp70 inhibits apoptosis induced by sialic acid-binding lectin (leczyme)

Por TATSUTA, TAKEO, HOSONO, MASAHIRO, OGAWA, YUKIKO, INAGE, KYOKO, SUGAWARA, SHIGEKI, NITTA, KAZUO
Publicado em 2014

Cancer-Selective Induction of Apoptosis by Leczyme

Por Tatsuta, Takeo, Sugawara, Shigeki, Takahashi, Kohta, Ogawa, Yukiko, Hosono, Masahiro, Nitta, Kazuo
Publicado em 2014

Leczyme: A New Candidate Drug for Cancer Therapy

Por Tatsuta, Takeo, Sugawara, Shigeki, Takahashi, Kohta, Ogawa, Yukiko, Hosono, Masahiro, Nitta, Kazuo
Publicado em 2014

RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells

Por Kariya, Yukiko, Tatsuta, Takeo, Sugawara, Shigeki, Kariya, Yoshinobu, Nitta, Kazuo, Hosono, Masahiro
Publicado no Int J Oncol (2016)

Sialic acid-binding lectin (leczyme) induces caspase-dependent apoptosis-mediated mitochondrial perturbation in Jurkat cells

Por TATSUTA, TAKEO, HOSONO, MASAHIRO, SUGAWARA, SHIGEKI, KARIYA, YUKIKO, OGAWA, YUKIKO, HAKOMORI, SENITIROH, NITTA, KAZUO
Publicado em 2013

Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs

Por TATSUTA, TAKEO, HOSONO, MASAHIRO, MIURA, YUKI, SUGAWARA, SHIGEKI, KARIYA, YUKIKO, HAKOMORI, SENITIROH, NITTA, KAZUO
Publicado em 2013

Sialic acid-binding lectin (leczyme) induces apoptosis to malignant mesothelioma and exerts synergistic antitumor effects with TRAIL

Por TATSUTA, TAKEO, HOSONO, MASAHIRO, TAKAHASHI, KOHTA, OMOTO, TAKASHI, KARIYA, YUKIKO, SUGAWARA, SHIGEKI, HAKOMORI, SENITIROH, NITTA, KAZUO
Publicado em 2013

Potentiation of Epidermal Growth Factor-Mediated Oncogenic Transformation by Sialidase NEU3 Leading to Src Activation

Por Yamamoto, Koji, Takahashi, Kohta, Shiozaki, Kazuhiro, Yamaguchi, Kazunori, Moriya, Setsuko, Hosono, Masahiro, Shima, Hiroshi, Miyagi, Taeko
Publicado no PLoS One (2015)

Upregulation of sialidase NEU3 in head and neck squamous cell carcinoma associated with lymph node metastasis

Por Shiga, Kiyoto, Takahashi, Kohta, Sato, Ikuro, Kato, Kengo, Saijo, Shigeru, Moriya, Setsuko, Hosono, Masahiro, Miyagi, Taeko
Publicado no Cancer Sci (2015)

Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons

Por Takahashi, Kohta, Mitoma, Junya, Hosono, Masahiro, Shiozaki, Kazuhiro, Sato, Chihiro, Yamaguchi, Kazunori, Kitajima, Ken, Higashi, Hideyoshi, Nitta, Kazuo, Shima, Hiroshi, Miyagi, Taeko
Publicado em 2012

Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum

Por Hata, Keiko, Tochigi, Tatsuo, Sato, Ikuro, Kawamura, Sadafumi, Shiozaki, Kazuhiro, Wada, Tadashi, Takahashi, Kohta, Moriya, Setsuko, Yamaguchi, Kazunori, Hosono, Masahiro, Miyagi, Taeko
Publicado no Cancer Sci (2015)

A Lectin from the Mussel Mytilus galloprovincialis Has a Highly Novel Primary Structure and Induces Glycan-mediated Cytotoxicity of Globotriaosylceramide-expressing Lymphoma Cells

Por Fujii, Yuki, Dohmae, Naoshi, Takio, Koji, Kawsar, Sarkar M. A., Matsumoto, Ryo, Hasan, Imtiaj, Koide, Yasuhiro, Kanaly, Robert A., Yasumitsu, Hidetaro, Ogawa, Yukiko, Sugawara, Shigeki, Hosono, Masahiro, Nitta, Kazuo, Hamako, Jiharu, Matsui, Taei, Ozeki, Yasuhiro
Publicado em 2012

A lectin from the mussel Mytilus galloprovincialis has a highly novel primary structure and induces glycan-mediated cytotoxicity of globotriaosylceramide-expressing lymphoma cells.

Por Fujii, Yuki, Dohmae, Naoshi, Takio, Koji, Kawsar, Sarkar M. A., Matsumoto, Ryo, Hasan, Imtiaj, Koide, Yasuhiro, Kanaly, Robert A., Yasumitsu, Hidetaro, Ogawa, Yukiko, Sugawara, Shigeki, Hosono, Masahiro, Nitta, Kazuo, Hamako, Jiharu, Matsui, Taei, Ozeki, Yasuhiro
Publicado em 2013

Cytotoxicity and Glycan-Binding Properties of an 18 kDa Lectin Isolated from the Marine Sponge Halichondria okadai

Por Matsumoto, Ryo, Fujii, Yuki, Kawsar, Sarkar M. A., Kanaly, Robert A., Yasumitsu, Hidetaro, Koide, Yasuhiro, Hasan, Imtiaj, Iwahara, Chihiro, Ogawa, Yukiko, Im, Chang Hun, Sugawara, Shigeki, Hosono, Masahiro, Nitta, Kazuo, Hamako, Jiharu, Matsui, Taei, Ozeki, Yasuhiro
Publicado em 2012

MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt’s Lymphoma Cells to Trigger Apoptosis through Multiple Pathways

Por Hasan, Imtiaj, Sugawara, Shigeki, Fujii, Yuki, Koide, Yasuhiro, Terada, Daiki, Iimura, Naoya, Fujiwara, Toshiyuki, Takahashi, Keisuke G., Kojima, Nobuhiko, Rajia, Sultana, Kawsar, Sarkar M. A., Kanaly, Robert A., Uchiyama, Hideho, Hosono, Masahiro, Ogawa, Yukiko, Fujita, Hideaki, Hamako, Jiharu, Matsui, Taei, Ozeki, Yasuhiro
Publicado no Mar Drugs (2015)