Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons

Modulation of levels of polysialic acid (polySia), a sialic acid polymer, predominantly associated with the neural cell adhesion molecule (NCAM), influences neural functions, including synaptic plasticity, neurite growth, and cell migration. Biosynthesis of polySia depends on two polysialyltransfera...

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Autori principali: Takahashi, Kohta, Mitoma, Junya, Hosono, Masahiro, Shiozaki, Kazuhiro, Sato, Chihiro, Yamaguchi, Kazunori, Kitajima, Ken, Higashi, Hideyoshi, Nitta, Kazuo, Shima, Hiroshi, Miyagi, Taeko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340223/
https://ncbi.nlm.nih.gov/pubmed/22393058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324186
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