Cytotoxicity and Glycan-Binding Properties of an 18 kDa Lectin Isolated from the Marine Sponge Halichondria okadai

A divalent cation-independent lectin—HOL-18, with cytotoxic activity against leukemia cells, was purified from a demosponge, Halichondria okadai. HOL-18 is a 72 kDa tetrameric lectin that consists of four non-covalently bonded 18 kDa subunits. Hemagglutination activity of the lectin was strongly inh...

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Detalhes bibliográficos
Principais autores: Matsumoto, Ryo, Fujii, Yuki, Kawsar, Sarkar M. A., Kanaly, Robert A., Yasumitsu, Hidetaro, Koide, Yasuhiro, Hasan, Imtiaj, Iwahara, Chihiro, Ogawa, Yukiko, Im, Chang Hun, Sugawara, Shigeki, Hosono, Masahiro, Nitta, Kazuo, Hamako, Jiharu, Matsui, Taei, Ozeki, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386633/
https://ncbi.nlm.nih.gov/pubmed/22778903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins4050323
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