GATA3 in Breast Cancer: Tumor Suppressor or Oncogene?

Por Takaku, Motoki, Grimm, Sara A., Wade, Paul A.
Publicado no Gene Expr (2015)

Extending Rare-Variant Testing Strategies: Analysis of Noncoding Sequence and Imputed Genotypes

Por Zawistowski, Matthew, Gopalakrishnan, Shyam, Ding, Jun, Li, Yun, Grimm, Sara, Zöllner, Sebastian
Publicado em 2010

Fine-tuning of epigenetic regulation with respect to promoter CpG content in a cell type-specific manner

Por Li, Ruifang, Mav, Deepak, Grimm, Sara A, Jothi, Raja, Shah, Ruchir, Wade, Paul A
Publicado em 2014

Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover

Por Adomas, Aleksandra B, Grimm, Sara A, Malone, Christine, Takaku, Motoki, Sims, Jennifer K, Wade, Paul A
Publicado em 2014

MBD3 Localizes at Promoters, Gene Bodies and Enhancers of Active Genes

Por Shimbo, Takashi, Du, Ying, Grimm, Sara A., Dhasarathy, Archana, Mav, Deepak, Shah, Ruchir R., Shi, Huidong, Wade, Paul A.
Publicado em 2013

Research Resource: Whole-Genome Estrogen Receptor α Binding in Mouse Uterine Tissue Revealed by ChIP-Seq

Por Hewitt, Sylvia C., Li, Leping, Grimm, Sara A., Chen, Yu, Liu, Liwen, Li, Yin, Bushel, Pierre R., Fargo, David, Korach, Kenneth S.
Publicado em 2012

An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression

Por Qin, Yufeng, Roberts, John D., Grimm, Sara A., Lih, Fred B., Deterding, Leesa J., Li, Ruifang, Chrysovergis, Kaliopi, Wade, Paul A.
Publicado no Genome Biol (2018)

Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer

Por Li, Ruifang, Grimm, Sara A., Mav, Deepak, Gu, Haiwei, Djukovic, Danijel, Shah, Ruchir, Merrick, B. Alex, Raftery, Daniel, Wade, Paul A.
Publicado no Cell Rep (2018)

LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells

Por Yang, Jun, Bennett, Brian D., Luo, Shujun, Inoue, Kaoru, Grimm, Sara A., Schroth, Gary P., Bushel, Pierre R., Kinyamu, H. Karimi, Archer, Trevor K.
Publicado no Mol Cell Biol (2015)

GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler

Por Takaku, Motoki, Grimm, Sara A., Shimbo, Takashi, Perera, Lalith, Menafra, Roberta, Stunnenberg, Hendrik G., Archer, Trevor K., Machida, Shinichi, Kurumizaka, Hitoshi, Wade, Paul A.
Publicado no Genome Biol (2016)

Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1

Por Hewitt, Sylvia C., Winuthayanon, Wipawee, Lierz, Sydney L., Hamilton, Katherine J., Donoghue, Lauren J., Ramsey, J. Tyler, Grimm, Sara A., Arao, Yukitomo, Korach, Kenneth S.
Publicado no Endocrinology (2017)

DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation

Por Lai, Anne Y., Mav, Deepak, Shah, Ruchir, Grimm, Sara A., Phadke, Dhiral, Hatzi, Katerina, Melnick, Ari, Geigerman, Cissy, Sobol, Steve E., Jaye, David L., Wade, Paul A.
Publicado em 2013

Obesity, rather than diet, drives epigenomics alterations in colonic epithelium resembling cancer progression

Por Li, Ruifang, Grimm, Sara A., Chrysovergis, Kaliopi, Kosak, Justin, Wang, Xingya, Du, Ying, Burkholder, Adam, Janardhan, Kyathanahalli, Mav, Deepak, Shah, Ruchir, Eling, Thomas E., Wade, Paul A.
Publicado em 2014

The novel p53 target TNFAIP8 variant 2 is increased in cancer and offsets p53-dependent tumor suppression

Por Lowe, Julie M, Nguyen, Thuy-Ai, Grimm, Sara A, Gabor, Kristin A, Peddada, Shyamal D, Li, Leping, Anderson, Carl W, Resnick, Michael A, Menendez, Daniel, Fessler, Michael B
Publicado no Cell Death Differ (2017)

Novel DNA Motif Binding Activity Observed In Vivo With an Estrogen Receptor α Mutant Mouse

Por Hewitt, Sylvia C., Li, Leping, Grimm, Sara A., Winuthayanon, Wipawee, Hamilton, Katherine J., Pockette, Brianna, Rubel, Cory A., Pedersen, Lars C., Fargo, David, Lanz, Rainer B., DeMayo, Francesco J., Schütz, Günther, Korach, Kenneth S.
Publicado em 2014

MapSplice: Accurate mapping of RNA-seq reads for splice junction discovery

Por Wang, Kai, Singh, Darshan, Zeng, Zheng, Coleman, Stephen J., Huang, Yan, Savich, Gleb L., He, Xiaping, Mieczkowski, Piotr, Grimm, Sara A., Perou, Charles M., MacLeod, James N., Chiang, Derek Y., Prins, Jan F., Liu, Jinze
Publicado em 2010

An APOBEC Cytidine Deaminase Mutagenesis Pattern is Widespread in Human Cancers

Por Roberts, Steven A., Lawrence, Michael S., Klimczak, Leszek J., Grimm, Sara A., Fargo, David, Stojanov, Petar, Kiezun, Adam, Kryukov, Gregory V., Carter, Scott L., Saksena, Gordon, Harris, Shawn, Shah, Ruchir R., Resnick, Michael A., Getz, Gad, Gordenin, Dmitry A.
Publicado em 2013

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts

Por Saini, Natalie, Roberts, Steven A., Klimczak, Leszek J., Chan, Kin, Grimm, Sara A., Dai, Shuangshuang, Fargo, David C., Boyer, Jayne C., Kaufmann, William K., Taylor, Jack A., Lee, Eunjung, Cortes-Ciriano, Isidro, Park, Peter J., Schurman, Shepherd H., Malc, Ewa P., Mieczkowski, Piotr A., Gordenin, Dmitry A.
Publicado no PLoS Genet (2016)