An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression

BACKGROUND: The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin features and, ultimately, gene expression. How the...

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Опубликовано в: :Genome Biol
Главные авторы: Qin, Yufeng, Roberts, John D., Grimm, Sara A., Lih, Fred B., Deterding, Leesa J., Li, Ruifang, Chrysovergis, Kaliopi, Wade, Paul A.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5782396/
https://ncbi.nlm.nih.gov/pubmed/29361968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1389-1
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