First Chemical Feature Based Pharmacophore Modeling of Potent Retinoidal Retinoic Acid Metabolism Blocking Agents (RAMBAs): Identification of Novel RAMBA Scaffolds

Por Purushottamachar, Puranik, Patel, Jyoti B., Gediya, Lalji K, Clement, Omoshile O., Njar, Vincent C. O.
Publicado em 2011

Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus

Por Goss, Paul E., Qi, Shangle, Hu, Haiqing, Gediya, Lalji K., Purushottamachar, Puranik, Godbole, Abhijit M., Njar, Vincent C. O.
Publicado em 2011

First Pharmacophore-Based Identification of Androgen Receptor Down-regulating Agents: Discovery of Potent Anti-Prostate Cancer Agents

Por Purushottamachar, Puranik, Khandelwal, Aakanksha, Chopra, Pankaj, Maheshwari, Neha, Gediya, Lalji K, Vasaitis, Tadas S., Bruno, Robert, Clement, Omoshile O., Njar, Vincent C. O.
Publicado em 2007

Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001) analogs: Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and a...

Por Bruno, Robert D., Vasaitis, Tadas S., Gediya, Lalji K., Purushottamachar, Puranik, Godbole, Abhijit M., Ates-Alagoz, Zeynep, Brodie, Angela M. H., Njar, Vincent C. O.
Publicado em 2011

The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer

Por Tran, Kim, Risingsong, Renee, B.Royce, Darlene, Williams, Charlotte R., Sporn, Michael B., Pioli, Patricia A., Gediya, Lalji K., Njar, Vincent C., Liby, Karen T.
Publicado em 2013

Systematic Structure Modifications of Multi-target Prostate Cancer Drug Candidate Galeterone to Produce Novel Androgen Receptor Down-regulating Agents as an Approach to Treatment o...

Por Purushottamachar, Puranik, Godbole, Abhijit M., Gediya, Lalji K., Martin, Marlena S., Vasaitis, Tadas S., Kwegyir-Afful, Andrew K., Ramalingam, Senthilmurugan, Ates-Alagoz, Zeynep, Njar, Vincent C. O.
Publicado em 2013

Androgen Receptor Inactivation Contributes to Antitumor Efficacy of CYP17 Inhibitor VN/124-1 in Prostate Cancer

Por Vasaitis, Tadas, Belosay, Aashvini, Schayowitz, Adam, Khandelwal, Aakanksha, Chopra, Pankaj, Gediya, Lalji K., Guo, Zhiyong, Fang, Hong-Bin, Njar, Vincent C. O., Brodie, Angela M. H.
Publicado em 2008

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors

Por Dexheimer, Thomas S., Gediya, Lalji K., Stephen, Andrew G., Weidlich, Iwona, Antony, Smitha, Marchand, Christophe, Interthal, Heidrun, Nicklaus, Marc, Fisher, Robert J., Njar, Vincent C., Pommier, Yves
Publicado em 2009

VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats

Por Godbole, Abhijit M., Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Khandelwal, Aakanksha, Bruno, Robert D., Upreti, Vijay V., Gediya, Lalji K., Purushottamachar, Puranik, Mbatia, Hannah W., Addya, Sankar, Ambulos, Nicholas, Njar, Vincent C. O.
Publicado em 2014