Systematic Structure Modifications of Multi-target Prostate Cancer Drug Candidate Galeterone to Produce Novel Androgen Receptor Down-regulating Agents as an Approach to Treatment of Advanced Prostate Cancer

As part of our program to explore the influence of small structural modifications of our drug candidate, 3β-(hydroxy)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene (galeterone, 5) on the modulation of the androgen receptor (AR), we have prepared and evaluated a series of novel C-3, C-16 and C-17 ana...

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Detaylı Bibliyografya
Asıl Yazarlar: Purushottamachar, Puranik, Godbole, Abhijit M., Gediya, Lalji K., Martin, Marlena S., Vasaitis, Tadas S., Kwegyir-Afful, Andrew K., Ramalingam, Senthilmurugan, Ates-Alagoz, Zeynep, Njar, Vincent C. O.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959744/
https://ncbi.nlm.nih.gov/pubmed/23713567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400048v
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