First Chemical Feature Based Pharmacophore Modeling of Potent Retinoidal Retinoic Acid Metabolism Blocking Agents (RAMBAs): Identification of Novel RAMBA Scaffolds

The first three-dimensional (3D) pharmacophore model was developed for potent retinoidal retinoic acid metabolism blocking agents (RAMBAs) with IC(50) values ranging from 0.0009 to 5.84 nM. The seven common chemical features in these RAMBAs as deduced by the Catalyst/HipHop program include five hydr...

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Main Authors: Purushottamachar, Puranik, Patel, Jyoti B., Gediya, Lalji K, Clement, Omoshile O., Njar, Vincent C. O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259215/
https://ncbi.nlm.nih.gov/pubmed/22130607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.11.010
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