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First Pharmacophore-Based Identification of Androgen Receptor Down-regulating Agents: Discovery of Potent Anti-Prostate Cancer Agents

A qualitative 3D pharmacophore model (a common feature based model or Catalyst HipHop algorithm) was developed for well known natural product androgen receptor down-regulating agents (ARDAs). The four common chemical features identified included: one hydrophobic group, one ring aromatic group and tw...

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Detalhes bibliográficos
Main Authors: Purushottamachar, Puranik, Khandelwal, Aakanksha, Chopra, Pankaj, Maheshwari, Neha, Gediya, Lalji K, Vasaitis, Tadas S., Bruno, Robert, Clement, Omoshile O., Njar, Vincent C. O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063997/
https://ncbi.nlm.nih.gov/pubmed/17383188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.03.019
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