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A New Simple and High-Yield Synthesis of 5α-Dihydrotestosterone (DHT), a Potent Androgen Receptor Agonist

We have devised an efficient procedure for the synthesis of 5α-dihydrotestosterone (DHT) (1) starting from 3β-hydroxy-5α-androstan-17-one, providing the product in unprecedented 82% yield. A reported method of using toxic Jones reagent is replaced by milder oxidizing agent (NMO/TPAP) in the synthesi...

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Autori principali: Purushottamachar, Puranik, Njar, Vincent C. O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959746/
https://ncbi.nlm.nih.gov/pubmed/23044354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2012.09.003
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