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Identification of the molecular switch that regulates access of 5α-DHT to the androgen receptor.
Pairs of hydroxysteroid dehydrogenases (HSDs) govern ligand access to steroid receptors in target tissues and act as molecular switches. By acting as reductases or oxidases, HSDs convert potent ligands into their cognate inactive metabolites or vice-versa. This pre-receptor regulation of steroid hor...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1857325/ https://ncbi.nlm.nih.gov/pubmed/17223255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2006.12.007 |
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