Androgen Receptor Inactivation Contributes to Antitumor Efficacy of CYP17 Inhibitor VN/124-1 in Prostate Cancer

We previously reported that our novel compound 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene (VN/124-1) is a potent CYP17 inhibitor/antiandrogen and strongly inhibits the formation and proliferation of human prostate cancer LAPC4 tumor xenografts in SCID mice. In this study, we report tha...

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Detalhes bibliográficos
Main Authors: Vasaitis, Tadas, Belosay, Aashvini, Schayowitz, Adam, Khandelwal, Aakanksha, Chopra, Pankaj, Gediya, Lalji K., Guo, Zhiyong, Fang, Hong-Bin, Njar, Vincent C. O., Brodie, Angela M. H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643345/
https://ncbi.nlm.nih.gov/pubmed/18723482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0230
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