Androgen Receptor Inactivation Contributes to Antitumor Efficacy of CYP17 Inhibitor VN/124-1 in Prostate Cancer

We previously reported that our novel compound 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene (VN/124-1) is a potent CYP17 inhibitor/antiandrogen and strongly inhibits the formation and proliferation of human prostate cancer LAPC4 tumor xenografts in SCID mice. In this study, we report tha...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Vasaitis, Tadas, Belosay, Aashvini, Schayowitz, Adam, Khandelwal, Aakanksha, Chopra, Pankaj, Gediya, Lalji K., Guo, Zhiyong, Fang, Hong-Bin, Njar, Vincent C. O., Brodie, Angela M. H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643345/
https://ncbi.nlm.nih.gov/pubmed/18723482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0230
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky