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Murine toxicology and pharmacokinetics evaluation of Retinoic Acid Metabolism Blocking Agent (RAMBA), VN/12-1

PURPOSE: Novel retinoic acid metabolism blocking agent (RAMBA), VN/12-1, is a highly potent anti-cancer agent which induces autophagy. Its combination with autophagy inhibitor chloroquine (CHL) has been shown to synergistically enhance apoptosis in breast cancer cells. The purpose of this study was...

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Détails bibliographiques
Auteurs principaux: Godbole, Abhijit M., Purushottamachar, Puranik, Martin, Marlena S., Njar, Vincent C. O.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959742/
https://ncbi.nlm.nih.gov/pubmed/22580781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1877-z
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