4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an enzyme that catalyzes the hydrolysis of 3'-phosphotyrosyl bonds. Such linkages form in vivo when topoisomerase I (Top1) processes DNA. For this reason, Tdp1 has been implicated in the repair of irreversible Top1-DNA covalent complexes. Tdp1 inhibitor...

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Detalhes bibliográficos
Main Authors: Dexheimer, Thomas S., Gediya, Lalji K., Stephen, Andrew G., Weidlich, Iwona, Antony, Smitha, Marchand, Christophe, Interthal, Heidrun, Nicklaus, Marc, Fisher, Robert J., Njar, Vincent C., Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784989/
https://ncbi.nlm.nih.gov/pubmed/19883083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901061s
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