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Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1 (TDP1)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) catalyzes the hydrolysis of phosphodiester linkages between a DNA 3′ phosphate and a tyrosine residue as well as a variety of other DNA 3′ substituents, and has been implicated in the repair of covalent complexes involving eukaryotic type IB topoisomerases. To...

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Hlavní autoři: Interthal, Heidrun, Champoux, James J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151729/
https://ncbi.nlm.nih.gov/pubmed/21463258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101841
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