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Human Tdp1 Cleaves a Broad Spectrum of Substrates Including Phosphoamide Linkages

Human tyrosyl-DNA phosphodiesterase (Tdp1) hydrolyzes the phosphodiester bond between a DNA 3′ end and a tyrosyl moiety. In eukaryotic cells this type of linkage is found in stalled topoisomerase I-DNA covalent complexes and Tdp1 has been implicated in the repair of such complexes in vivo. We confir...

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Hlavní autoři: Interthal, Heidrun, Chen, Hong Jing, Champoux, James J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1351008/
https://ncbi.nlm.nih.gov/pubmed/16141202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M508898200
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