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Human Tdp1 Cleaves a Broad Spectrum of Substrates Including Phosphoamide Linkages
Human tyrosyl-DNA phosphodiesterase (Tdp1) hydrolyzes the phosphodiester bond between a DNA 3′ end and a tyrosyl moiety. In eukaryotic cells this type of linkage is found in stalled topoisomerase I-DNA covalent complexes and Tdp1 has been implicated in the repair of such complexes in vivo. We confir...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1351008/ https://ncbi.nlm.nih.gov/pubmed/16141202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M508898200 |
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