Physicochemical properties and Mycobacterium tuberculosis transporters: keys to efficacious antitubercular drugs?

por Fullam, Elizabeth, Young, Robert J.
Publicado en RSC Med Chem (2020)

Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile

por Otten, Lucienne, Fullam, Elizabeth, Gibson, Matthew I.
Publicado en Mol Biosyst (2016)

Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis

por Guy, Collette S., Gibson, Matthew I., Fullam, Elizabeth
Publicado en Chem Sci (2019)

Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars

por Fullam, Elizabeth, Prokes, Ivan, Fütterer, Klaus, Besra, Gurdyal S.
Publicado en Open Biol (2016)

Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis

por Sandy, James, Holton, Simon, Fullam, Elizabeth, Sim, Edith, Noble, Martin
Publicado 2005

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme

por Fullam, Elizabeth, Pojer, Florence, Bergfors, Terese, Jones, T. Alwyn, Cole, Stewart T.
Publicado 2012

A GFP-strategy for efficient recombinant protein overexpression and purification in Mycobacterium smegmatis

por Radhakrishnan, Anjana, Furze, Christopher M., Ahangar, Mohd Syed, Fullam, Elizabeth
Publicado en RSC Adv (2018)

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site

por Abuhammad, Areej M., Lowe, Edward D., Fullam, Elizabeth, Noble, Martin, Garman, Elspeth F., Sim, Edith
Publicado en Protein Cell (2010)

Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms

por Richards, Sarah-Jane, Isufi, Klea, Wilkins, Laura E., Lipecki, Julia, Fullam, Elizabeth, Gibson, Matthew I.
Publicado en Biomacromolecules (2017)

Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB

por Fenn, Jonathan S., Nepravishta, Ridvan, Guy, Collette S., Harrison, James, Angulo, Jesus, Cameron, Alexander D., Fullam, Elizabeth
Publicado en ACS Chem Biol (2019)

Biochemical and phenotypic characterisation of the Mycobacterium smegmatis transporter UspABC

por Karlikowska, Magdalena, Singh, Albel, Bhatt, Apoorva, Ott, Sascha, Bottrill, Andrew R., Besra, Gurdyal S., Fullam, Elizabeth
Publicado en Cell Surf (2021)

Exploration of Piperidinols as Potential Antitubercular Agents

por Abuhammad, Areej, Fullam, Elizabeth, Bhakta, Sanjib, Russell, Angela J., Morris, Garrett M., Finn, Paul W., Sim, Edith
Publicado en Molecules (2014)

Osmium–arene complexes with high potency towards Mycobacterium tuberculosis

por Coverdale, James P C, Guy, Collette S, Bridgewater, Hannah E, Needham, Russell J, Fullam, Elizabeth, Sadler, Peter J
Publicado en Metallomics (2021)

Arylamine N-Acetyltransferases in Mycobacteria

por Sim, Edith, Sandy, James, Evangelopoulos, Dimitrios, Fullam, Elizabeth, Bhakta, Sanjib, Westwood, Isaac, Krylova, Anna, Lack, Nathan, Noble, Martin
Publicado 2008

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA)

por Ahangar, Mohd Syed, Furze, Christopher M., Guy, Collette S., Cooper, Charlotte, Maskew, Kathryn S., Graham, Ben, Cameron, Alexander D., Fullam, Elizabeth
Publicado en J Biol Chem (2018)

Evaluation of the Antimicrobial Activity of Cationic Polymers against Mycobacteria: Toward Antitubercular Macromolecules

por Phillips, Daniel J., Harrison, James, Richards, Sarah-Jane, Mitchell, Daniel E., Tichauer, Esther, Hubbard, Alasdair T. M., Guy, Collette, Hands-Portman, Ian, Fullam, Elizabeth, Gibson, Matthew I.
Publicado en Biomacromolecules (2017)

Identification of the anti‐mycobacterial functional properties of piperidinol derivatives

por Guy, Collette S, Tichauer, Esther, Kay, Gemma L, Phillips, Daniel J, Bailey, Trisha L, Harrison, James, Furze, Christopher M, Millard, Andrew D, Gibson, Matthew I, Pallen, Mark J, Fullam, Elizabeth
Publicado en Br J Pharmacol (2017)

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars

por Westwood, Isaac M., Bhakta, Sanjib, Russell, Angela J., Fullam, Elizabeth, Anderton, Matthew C., Kawamura, Akane, Mulvaney, Andrew W., Vickers, Richard J., Bhowruth, Veemal, Besra, Gurdyal S., Lalvani, Ajit, Davies, Stephen G., Sim, Edith
Publicado en Protein Cell (2010)

Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter

por Furze, Christopher M., Delso, Ignacio, Casal, Enriqueta, Guy, Collette S., Seddon, Chloe, Brown, Chelsea M., Parker, Hadyn L., Radhakrishnan, Anjana, Pacheco-Gomez, Raul, Stansfeld, Phillip J., Angulo, Jesus, Cameron, Alexander D., Fullam, Elizabeth
Publicado en J Biol Chem (2021)

Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages

por Abuhammad, Areej, Fullam, Elizabeth, Lowe, Edward D., Staunton, David, Kawamura, Akane, Westwood, Isaac M., Bhakta, Sanjib, Garner, Alun Christopher, Wilson, David L., Seden, Peter T., Davies, Stephen G., Russell, Angela J., Garman, Elspeth F., Sim, Edith
Publicado 2012