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Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme

The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme. Here, we report on the structural and kinetic characterization of the transketolase from M. tuberculosis (TBTKT), a homodimer...

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Main Authors: Fullam, Elizabeth, Pojer, Florence, Bergfors, Terese, Jones, T. Alwyn, Cole, Stewart T.
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352088/
https://ncbi.nlm.nih.gov/pubmed/22645655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.110026
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