Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis

BTZ043, a tuberculosis drug candidate with nanomolar whole-cell activity, targets the DprE1 enzyme of the essential decaprenylphosphoryl-β-D-ribofuranose-2′-epimerase thus blocking biosynthesis of arabinans, vital cell-wall components of mycobacteria. Crystal structures of DprE1, in its native form...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Neres, João, Pojer, Florence, Molteni, Elisabetta, Chiarelli, Laurent R., Dhar, Neeraj, Boy-Röttger, Stefanie, Buroni, Silvia, Fullam, Elizabeth, Degiacomi, Giulia, Lucarelli, Anna Paola, Read, Randy J., Zanoni, Giuseppe, Edmondson, Dale E., De Rossi, Edda, Pasca, Maria Rosalia, McKinney, John D., Dyson, Paul J., Riccardi, Giovanna, Mattevi, Andrea, Cole, Stewart T., Binda, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659392/
https://ncbi.nlm.nih.gov/pubmed/22956199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004395
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados