Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis

BTZ043, a tuberculosis drug candidate with nanomolar whole-cell activity, targets the DprE1 enzyme of the essential decaprenylphosphoryl-β-D-ribofuranose-2′-epimerase thus blocking biosynthesis of arabinans, vital cell-wall components of mycobacteria. Crystal structures of DprE1, in its native form...

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Main Authors: Neres, João, Pojer, Florence, Molteni, Elisabetta, Chiarelli, Laurent R., Dhar, Neeraj, Boy-Röttger, Stefanie, Buroni, Silvia, Fullam, Elizabeth, Degiacomi, Giulia, Lucarelli, Anna Paola, Read, Randy J., Zanoni, Giuseppe, Edmondson, Dale E., De Rossi, Edda, Pasca, Maria Rosalia, McKinney, John D., Dyson, Paul J., Riccardi, Giovanna, Mattevi, Andrea, Cole, Stewart T., Binda, Claudia
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659392/
https://ncbi.nlm.nih.gov/pubmed/22956199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004395
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