Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis

BTZ043, a tuberculosis drug candidate with nanomolar whole-cell activity, targets the DprE1 enzyme of the essential decaprenylphosphoryl-β-D-ribofuranose-2′-epimerase thus blocking biosynthesis of arabinans, vital cell-wall components of mycobacteria. Crystal structures of DprE1, in its native form...

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Bibliografiske detaljer
Main Authors: Neres, João, Pojer, Florence, Molteni, Elisabetta, Chiarelli, Laurent R., Dhar, Neeraj, Boy-Röttger, Stefanie, Buroni, Silvia, Fullam, Elizabeth, Degiacomi, Giulia, Lucarelli, Anna Paola, Read, Randy J., Zanoni, Giuseppe, Edmondson, Dale E., De Rossi, Edda, Pasca, Maria Rosalia, McKinney, John D., Dyson, Paul J., Riccardi, Giovanna, Mattevi, Andrea, Cole, Stewart T., Binda, Claudia
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659392/
https://ncbi.nlm.nih.gov/pubmed/22956199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004395
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