Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages

Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection. Catabolism of cholesterol contributes to the pool of propionyl-C...

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Detalhes bibliográficos
Main Authors: Abuhammad, Areej, Fullam, Elizabeth, Lowe, Edward D., Staunton, David, Kawamura, Akane, Westwood, Isaac M., Bhakta, Sanjib, Garner, Alun Christopher, Wilson, David L., Seden, Peter T., Davies, Stephen G., Russell, Angela J., Garman, Elspeth F., Sim, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532304/
https://ncbi.nlm.nih.gov/pubmed/23285185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052790
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