Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?

Por Ford, Rebecca J., Desjardins, Eric M., Steinberg, Gregory R.
Publicado no EBioMedicine (2017)

Chronic in vivo or acute in vitro resveratrol attenuates endothelium-dependent cyclooxygenase-mediated contractile signaling in hypertensive rat carotid artery

Por Denniss, Steven G., Ford, Rebecca J., Smith, Christopher S., Jeffery, Andrew J., Rush, James W. E.
Publicado no J Appl Physiol (1985) (2016)

Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression

Por Lally, James S V, Ford, Rebecca J, Johar, Jasper, Crane, Justin D, Kemp, Bruce E, Steinberg, Gregory R
Publicado no Physiol Rep (2015)

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

Por Ducommun, Serge, Ford, Rebecca J., Bultot, Laurent, Deak, Maria, Bertrand, Luc, Kemp, Bruce E., Steinberg, Gregory R., Sakamoto, Kei
Publicado em 2014

Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis

Por Basseri, Sana, Lhoták, Šárka, Fullerton, Morgan D., Palanivel, Rengasamy, Jiang, Hua, Lynn, Edward G., Ford, Rebecca J., Maclean, Kenneth N., Steinberg, Gregory R., Austin, Richard C.
Publicado em 2013

Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise

Por O’Neill, Hayley M, Lally, James S, Galic, Sandra, Pulinilkunnil, Thomas, Ford, Rebecca J, Dyck, Jason R B, van Denderen, Bryce J, Kemp, Bruce E, Steinberg, Gregory R
Publicado no Physiol Rep (2015)

The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration

Por Villani, Linda A., Smith, Brennan K., Marcinko, Katarina, Ford, Rebecca J., Broadfield, Lindsay A., Green, Alex E., Houde, Vanessa P., Muti, Paola, Tsakiridis, Theodoros, Steinberg, Gregory R.
Publicado no Mol Metab (2016)

Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging

Por Crane, Justin D, MacNeil, Lauren G, Lally, James S, Ford, Rebecca J, Bujak, Adam L, Brar, Ikdip K, Kemp, Bruce E, Raha, Sandeep, Steinberg, Gregory R, Tarnopolsky, Mark A
Publicado no Aging Cell (2015)

The Na(+)/glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels

Por Hawley, Simon A., Ford, Rebecca J., Smith, Brennan K., Gowans, Graeme J., Mancini, Sarah J., Pitt, Ryan D., Day, Emily A., Salt, Ian P., Steinberg, Gregory R., Hardie, D. Grahame
Publicado no Diabetes (2016)

PPARδ activation attenuates hepatic steatosis in Ldlr(−/−) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

Por Bojic, Lazar A., Telford, Dawn E., Fullerton, Morgan D., Ford, Rebecca J., Sutherland, Brian G., Edwards, Jane Y., Sawyez, Cynthia G., Gros, Robert, Kemp, Bruce E., Steinberg, Gregory R., Huff, Murray W.
Publicado em 2014

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

Por Bujak, Adam L., Crane, Justin D., Lally, James S., Ford, Rebecca J., Kang, Sally J., Rebalka, Irena A., Green, Alex E., Kemp, Bruce E., Hawke, Thomas J., Schertzer, Jonathan D., Steinberg, Gregory R.
Publicado no Cell Metab (2015)

The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

Por Marcinko, Katarina, Bujak, Adam L., Lally, James S.V., Ford, Rebecca J., Wong, Tammy H., Smith, Brennan K., Kemp, Bruce E., Jenkins, Yonchu, Li, Wei, Kinsella, Todd M., Hitoshi, Yasumichi, Steinberg, Gregory R.
Publicado no Mol Metab (2015)

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Por Pinkosky, Stephen L., Newton, Roger S., Day, Emily A., Ford, Rebecca J., Lhotak, Sarka, Austin, Richard C., Birch, Carolyn M., Smith, Brennan K., Filippov, Sergey, Groot, Pieter H.E., Steinberg, Gregory R., Lalwani, Narendra D.
Publicado no Nat Commun (2016)

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

Por Fullerton, Morgan D., Ford, Rebecca J., McGregor, Chelsea P., LeBlond, Nicholas D., Snider, Shayne A., Stypa, Stephanie A., Day, Emily A., Lhoták, Šárka, Schertzer, Jonathan D., Austin, Richard C., Kemp, Bruce E., Steinberg, Gregory R.
Publicado no J Lipid Res (2015)

Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants

Por Boyle, Kristen E., Patinkin, Zachary W., Shapiro, Allison L.B., Bader, Carly, Vanderlinden, Lauren, Kechris, Katerina, Janssen, Rachel C., Ford, Rebecca J., Smith, Brennan K., Steinberg, Gregory R., Davidson, Elizabeth J., Yang, Ivana V., Dabelea, Dana, Friedman, Jacob E.
Publicado no Mol Metab (2017)

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

Por Ford, Rebecca J., Fullerton, Morgan D., Pinkosky, Stephen L., Day, Emily A., Scott, John W., Oakhill, Jonathan S., Bujak, Adam L., Smith, Brennan K., Crane, Justin D., Blumer, Regje M., Marcinko, Katarina, Kemp, Bruce E., Gerstein, Hertzel C., Steinberg, Gregory R.
Publicado no Biochem J (2015)

Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities

Por Pulito, Claudio, Mori, Federica, Sacconi, Andrea, Goeman, Frauke, Ferraiuolo, Maria, Pasanisi, Patrizia, Campagnoli, Carlo, Berrino, Franco, Fanciulli, Maurizio, Ford, Rebecca J, Levrero, Massimo, Pediconi, Natalia, Ciuffreda, Ludovica, Milella, Michele, Steinberg, Gregory R, Cioce, Mario, Muti, Paola, Strano, Sabrina, Blandino, Giovanni
Publicado no Cell Discov (2017)

Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1

Por Smith, Brennan K., Ford, Rebecca J., Desjardins, Eric M., Green, Alex E., Hughes, Meghan C., Houde, Vanessa P., Day, Emily A., Marcinko, Katarina, Crane, Justin D., Mottillo, Emilio P., Perry, Christopher G.R., Kemp, Bruce E., Tarnopolsky, Mark A., Steinberg, Gregory R.
Publicado no Diabetes (2016)

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin

Por Fullerton, Morgan D., Galic, Sandra, Marcinko, Katarina, Sikkema, Sarah, Pulinilkunnil, Thomas, Chen, Zhi–Ping, O’Neill, Hayley M., Ford, Rebecca J., Palanivel, Rengasamy, O’Brien, Matthew, Hardie, D. Grahame, Macaulay, S. Lance, Schertzer, Jonathan D., Dyck, Jason R. B., van Denderen, Bryce J., Kemp, Bruce E., Steinberg, Gregory R.
Publicado no Nat Med (2013)

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

Por Crane, Justin D, Palanivel, Rengasamy, Mottillo, Emilio P, Bujak, Adam L, Wang, Huaqing, Ford, Rebecca J, Collins, Andrew, Blümer, Regje M, Fullerton, Morgan D, Yabut, Julian M, Kim, Janice J, Ghia, Jean-Eric, Hamza, Shereen M, Morrison, Katherine M, Schertzer, Jonathan D, Dyck, Jason R B, Khan, Waliul I, Steinberg, Gregory R
Publicado no Nat Med (2014)