Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1

Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces nonalcoholic fatty liver disease (NAFLD) in animal models; however, the mechanism mediating these effects is unclear. Salicylate directly activates AMPK via the β1 subunit, but whether s...

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Udgivet i:Diabetes
Main Authors: Smith, Brennan K., Ford, Rebecca J., Desjardins, Eric M., Green, Alex E., Hughes, Meghan C., Houde, Vanessa P., Day, Emily A., Marcinko, Katarina, Crane, Justin D., Mottillo, Emilio P., Perry, Christopher G.R., Kemp, Bruce E., Tarnopolsky, Mark A., Steinberg, Gregory R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233442/
https://ncbi.nlm.nih.gov/pubmed/27554471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0564
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