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Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1

Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces nonalcoholic fatty liver disease (NAFLD) in animal models; however, the mechanism mediating these effects is unclear. Salicylate directly activates AMPK via the β1 subunit, but whether s...

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Библиографические подробности
Опубликовано в: :	Diabetes
Главные авторы:	Smith, Brennan K., Ford, Rebecca J., Desjardins, Eric M., Green, Alex E., Hughes, Meghan C., Houde, Vanessa P., Day, Emily A., Marcinko, Katarina, Crane, Justin D., Mottillo, Emilio P., Perry, Christopher G.R., Kemp, Bruce E., Tarnopolsky, Mark A., Steinberg, Gregory R.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	2016
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5233442/ https://ncbi.nlm.nih.gov/pubmed/27554471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0564
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Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1

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