The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

OBJECTIVE: Skeletal muscle AMP-activated protein kinase (AMPK) is important for regulating glucose homeostasis, mitochondrial content and exercise capacity. R419 is a mitochondrial complex-I inhibitor that has recently been shown to acutely activate AMPK in myotubes. Our main objective was to examin...

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Библиографические подробности
Опубликовано в: :Mol Metab
Главные авторы: Marcinko, Katarina, Bujak, Adam L., Lally, James S.V., Ford, Rebecca J., Wong, Tammy H., Smith, Brennan K., Kemp, Bruce E., Jenkins, Yonchu, Li, Wei, Kinsella, Todd M., Hitoshi, Yasumichi, Steinberg, Gregory R.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2015
Предметы:
Brief Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563030/
https://ncbi.nlm.nih.gov/pubmed/26413470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.06.002
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