AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

The AMP-activated protein kinase (AMPK) activates autophagy, but its role in aging and fasting-induced muscle function has not been defined. Here we report that fasting mice lacking skeletal muscle AMPK (AMPK-MKO) results in hypoglycemia and hyperketosis. This is not due to defective fatty acid oxid...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cell Metab
Main Authors: Bujak, Adam L., Crane, Justin D., Lally, James S., Ford, Rebecca J., Kang, Sally J., Rebalka, Irena A., Green, Alex E., Kemp, Bruce E., Hawke, Thomas J., Schertzer, Jonathan D., Steinberg, Gregory R.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233441/
https://ncbi.nlm.nih.gov/pubmed/26039451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.05.016
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares