Muscle-specific AMPK β1β2-null mice display a myopathy due to loss of capillary density in nonpostural muscles

AMP-activated protein kinase (AMPK) is a master regulator of metabolism. While muscle-specific AMPK β1β2 double-knockout (β1β2M-KO) mice display alterations in metabolic and mitochondrial capacity, their severe exercise intolerance suggested a secondary contributor to the observed phenotype. We find...

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Detalhes bibliográficos
Main Authors: Thomas, Melissa M., Wang, David C., D'Souza, Donna M., Krause, Matthew P., Layne, Andrew S., Criswell, David S., O'Neill, Hayley M., Connor, Michael K., Anderson, Judy E., Kemp, Bruce E., Steinberg, Gregory R., Hawke, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986832/
https://ncbi.nlm.nih.gov/pubmed/24522207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-238972
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